Haworth, Brian T. Sutch, Rebecca M. Romero Objectives To evaluate faculty-led discussion meetings (with about eight students) conducted face-to-face (in-class) or by synchronous, real-time videoconference (online), in a biopharmaceutics course taught in a facilitated problem-based learning (PBL) format. Methods Three methods were used to compare in-class versus online discussion sessions for two semesters. The first method involved three parameters that measured the quality of interactions between faculty (facilitator) and student (Fc–St), participation of students in the discussions (Par), and student–student interactions (St–St). The second method assessed student’s perceptions of the discussions with surveys. The third method mapped the interactions (a sociogram) between faculty (facilitator) and students in a discussion. Results There were significantly lower scores for Par and St–St (P < 0.05)>

Physical aim and you can pharmacology out-of curcumin

Guide ChapterAsma Este-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Meters. Romero, Ian S Haworth Curcumin is the major element of the fresh new reddish color regarding turmeric, a keen Indian spice which is extracted from the newest rhizome of your warm plant Curcuma longa, and therefore belongs to the Zingiberaceae family unit members. Within this section, we talk about the pharmacological facts from curcumin and you may explore the brand new molecular basics for these issues. We up coming comment the latest confirmed and you will prospective medical uses from curcumin. Curcumin known historically as the a healing agent, but the method away from action is actually in depth. The latest pharmacological outcomes of curcumin be seemingly caused by an effective synergism off communities from poor biochemical relations having several physiological needs in the interconnected signaling paths. Such plans were nutrients including cyclooxygenase, lipoxygenase and healthy protein kinases, and you will transcription facts instance NF-?B, STAT and Nrf2. Modulation of these molecules has an effect on downstream affectors which make the antiinflammatory, antioxidant, chemopreventive, anticancer, and antimicrobial products regarding curcumin. This type of effects attraktive Dominikanere kvinder had been looked at in systematic products away from curcumin to possess serious pain and you will inflammatory diseases, malignant tumors, Alzheimer problem, cardiovascular infection, and diabetes. The brand new products have tried variable dosage out of curcuminwith various other wavelengths and you may cycle, to your standard end one higher dosage away from curcumin at level of grams must obtain healing effects. Read more

Curcumin: Synthesis, Growing Role in the Aches Management and you may Health Effects

Book Part Examples of plant-derived pharmaceuticals with get to be the interest from proceeded and you can exponential browse and you may creativity appeal have, so far, already been somewhat scarce. Immediately following several years, the past twenty years have been characterized by a good 100-fold escalation in the amount of medical posts wrote annually that try out-of significance into the means to access curcumin inside the biomedicine. Read more

Framework, synthesis and biological things of curcumin prodrugs

Publication ChapterAsma El-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Yards. Romero, Ian S Haworth Curcumin has many prospective pharmacological consequences and may provides therapeutic software in several problem says, since talked about in more detail in the last part. not, the potential logical effectiveness away from curcumin is bound by the their physicochemical attributes away from worst liquid solubility and you will instability, and this end up in reduced bioavailability. Prodrugs off curcumin promote an easy way to update of your biopharmaceutical and you can pharmacokinetic features, and may ensure it is exploitation of the pharmacological ramifications of curcumin. Within this chapter, i basic feedback brand new physicochemical and pharmacokinetics out of curcumin. We upcoming explain the appearance of curcumin prodrugs with increased drinking water solubility and you may increased chemicals stability that can be translated to 100 % free curcumin abreast of bioactivation inside vivo. We high light present profits in this field, with a concentrate on the construction, synthesis and you will analysis away from prodrugs predicated on promoieties including proteins, essential fatty acids, nucleic acids, dicarboxylic acids, and polymeric materials such hyaluronic acid and you can polyethylene glycol. That it chapter gets the basis for optimisation of your own physicochemical and you can biopharmaceutical features while the physical activities of curcumin prodrugs, to the goal using of them curcumin types in the medical apps. Find out more